Table 2. Heart function in C57BL/6 and DBA/2 mice following two weeks of isoproterenol treatment.
| Parameters | Treatment | |||
|---|---|---|---|---|
| C57BL/6 Control | C57BL/6 Isoproterenol | DBA/2 Control | DBA/2 Isoproterenol | |
| Bw (g) | 20.04 ± 0.33 | 21.75 ± 0.31 | 22.03 ± 0.63 | 21.93 ± 0.56 |
| IVS d (mm) | 0.7373 ± 0.038 | 0.9164 ± 0.066 # | 0.8458 ± 0.043 | 0.9633 ± 0.04 |
| IVS s (mm) | 0.9609 ± 0.046 | 1.463 ± 0.091 # | 1.078± 0.052 | 1.356 ± 0.056 # |
| LVID d (mm) | 3.194 ± 0.079 | 2.997 ± 0.107 | 3.397 ± 0.115 | 3.541 ± 0.083* |
| LVID s (mm) | 2.289 ± 0.061 | 1.573 ± 0.119 # | 2.389 ± 0.073 | 2.343 ± 0.095* |
| LVPW d (mm) | 0.9727 ± 0.061 | 1.44 ± 0.11 # | 1.001 ± 0.062 | 1.439 ± 0.077 # |
| LVPW s (mm) | 1.193 ± 0.065 | 1.79 ± 0.081 # | 1.277 ± 0.062 | 1.743 ± 0.067* # |
| FS % | 28.25 ± 1.22 | 47.27 ± 3.72 # | 29.41 ± 1.26 | 33.99 ± 1.66* # |
| EF % | 55.74 ± 1.80 | 78.21 ± 3.84 # | 57.27 ± 1.78 | 63.5 ± 2.33* |
| Hw (mg) | 71.88 ± 3.35 | 106 ± 6.86 # | 90.35 ± 7.33 | 140.3 ± 7.87* # |
| Hw:Bw (mg/g) | 3.583 ± 0.15 | 4.924 ± 0.331 # | 3.961 ± 0.30 | 6.435 ± 037* # |
All data are expressed as mean ± SEM
p < 0.05, student’s t-test
n = 11 (C57BL/6), 12 (DBA/2)
# indicates significant from control
*
indicates significant between strains
Abbreviations: BW, body weight; IVS, intraventricular septum; LVID, left ventricular internal diameter; LWPV, left ventricular posterior free wall; EF, ejection fraction; FS, fractional shortening; Hw, heart weight; Hw:Bw, heart weight : body weight; s, systole; d, diastole