Figure 6. Defining epitope’s minimal sequence.

Series of pin-tethered RYDERY derivatives were synthesized as described in Fig. 3. In one series individual amino acids were replaced with glycine, and in the other series amino acids were truncated one-by-one from the N-terminus. For both series antigenic activity for the peptides was determined as described in Fig. 3. The results are the average of three independent assays.