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. 2013 Aug 5;8(8):e70575. doi: 10.1371/journal.pone.0070575

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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A, Study design for the optimization and application of the syngeneic SHR/SST-2 model. SHRs were subcutaneously implanted with exponentially-growing SST-2 breast cancer cells in their right mammary fat pads. Doxorubicin and dexrazoxane were used as control chemotherapeutic and chemoprotective agents, respectively. Mito-T (4) was tested as a chemoprotective agent. In addition to overall tumor reduction and cardiac lesions, protein oxidation, DNA oxidation, autophagy, apoptosis, and necrosis were measured as mechanistic endpoints. B, Tumors were measured at days 1, 7, 10, and 14. Results are expressed as tumor volume. C, Serum from control and tumor-bearing SHRs was compared for levels of inflammatory cytokines, IL-1A, IL-4, IL-6, MCP-1, and TNF-α. Cardiac troponin T (cTnT) was compared as an indicator of cardiac toxicity. Mean values from 30 animals per group are shown.