Table 1. Behavior data summary for Cx-mGluR5 in 129/C57 background.

Behavioral paradigm	Measurement	Male		Female		Genotype effect	Gendereffect	Male+Female		Genotype effect
		WT	KO	WT	KO	p value	p value	WT	KO	p value
Open Field	total distance traveled (cm)	653.1±138.0 (15)	1566.0±182.3 (15)	1079.4±221.0 (16)	1543.7±356.2 (13)	0.004*	0.383	873.12±135.70 (31)	1555.61±188.19 (28)	0.004*
	movement time (s)	500.8±57.3 (15)	815.1±45.1 (15)	627.0±68.6 (16)	825.0±72.8 (13)	<0.001*	0.275	565.93±45.69 (31)	819.69±40.73 (28)	<0.001*
	movement speed (cm/s)	1.0±0.1 (15)	1.8±0.2 (15)	1.3±0.2 (16)	1.6±0.3 (13)	0.004*	0.721	1.11±0.12 (31)	1.67±0.14 (28)	0.004*
	vertical activity	24.5±8.1 (15)	94.9±21.1 (15)	49.4±15.2 (16)	77.5±26.0 (13)	0.009*	0.836	37.32±8.93 (31)	86.82±16.32 (28)	0.008
	center zone distance (cm)	53.7±18.6 (15)	118.9±42.1 (15)	102.9±44.8 (16)	225.6±100.1 (13)	0.097	0.165	79.11±24.80 (31)	168.16±51.63 (28)	0.114
	center zone duration (s)	28.4±6.4 (15)	39.0±10.2 (15)	34.4±9.6 (16)	66.1±21.7 (13)	0.096	0.190	31.53±5.77 (31)	51.61±11.51 (28)	0.114
	center distance ratio	0.06±0.02 (15)	0.07±0.02 (15)	0.06±0.01 (16)	0.10±0.03 (13)	0.269	0.538	0.06±0.01 (31)	0.08±0.02 (28)	0.285
RotoRod	latency to fall (s) trial 1	90.6±11.6 (11)	68.9±12.0 (10)	n.a.	n.a.	0.210	n.a.	n.a.	n.a.	n.a.
	latency to fall (s) trial 2	149.6±19.1 (11)	77.3±20.1 (10)	n.a.	n.a.	0.017*	n.a.	n.a.	n.a.	n.a.
	latency to fall (s) trial 3	155.2±22.9 (11)	128.2±26.9 (10)	n.a.	n.a.	0.451	n.a.	n.a.	n.a.	n.a.
	latency to fall (s) trial 4	163.5±23.1 (11)	135.8±25.6 (10)	n.a.	n.a.	0.432	n.a.	n.a.	n.a.	n.a.
	latency to fall (s) trial 5	197.4±26.9 (11)	187.4±24.3 (10)	n.a.	n.a.	0.788	n.a.	n.a.	n.a.	n.a.
	latency to fall (s) trial 6	220.4±22.2 (11)	201.2±30.4 (10)	n.a.	n.a.	0.612	n.a.	n.a.	n.a.	n.a.
	latency to fall (s) trial 7	230.8±26.4 (11)	204.3±30.4 (10)	n.a.	n.a.	0.516	n.a.	n.a.	n.a.	n.a.
	latency to fall (s) trial 8	234.3±23.5 (11)	227.6±27.6 (10)	n.a.	n.a.	0.855	n.a.	n.a.	n.a.	n.a.
	latency to fall (s) day 1	139.68±20.97 (11)	102.55±23.13 (10)	n.a.	n.a.	0.171	n.a.	n.a.	n.a.	n.a.
	latency to fall (s) day 2	220.70±24.33 (11)	205.13±27.58 (10)	n.a.	n.a.	0.234	n.a.	n.a.	n.a.	n.a.
Prepulse Inhibition	% PPI at 74 dB prepulse	29.9±6.1 (25)	21.8±6.2 (20)	16.3±4.2 (14)	16.0±6.9 (14)	0.285	0.135	25.02±4.26 (39)	19.42±4.56 (34)	0.373
	% PPI at 78 dB prepulse	51.0±6.4 (25)	42.2±6.7 (20)	30.4±5.1 (14)	28.1±6.7 (14)	0.513	0.012*	43.60±4.74 (39)	36.41±4.87 (34)	0.295
	% PPI at 82 dB prepulse	65.9±4.7 (25)	61.3±5.3 (20)	49.1±5.5 (14)	46.9±7.0 (14)	0.418	0.007*	59.88±3.78 (39)	55.36±4.34 (34)	0.433
	normalized startle response (A.U./g body weight)	664.2±103.6 (25)	934.4±135.9 (20)	700.6±91.5 (14)	686.6±98.4 (14)	0.549	0.377	677.29±73.34 (39)	832.36±90.96 (34)	0.184
Homecage	total activity in dark phase(# beam breaks)	3054.4±206.3 (14)	3395.6±279.2 (14)	n.a.	n.a.	0.335	n.a.	n.a.	n.a.	n.a.
	total activity in light phase(# beam breaks)	1196.4±109.1 (14)	1386.9±196.6 (14)	n.a.	n.a.	0.405	n.a.	n.a.	n.a.	n.a.

Values are listed as mean ± SEM (number of animals analyzed). Abbreviations: A.U., arbitrary unit;

^*, p<0.05.