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(A) Plasma spontaneous amidase activities and (B) proenzyme activation in patients suffering from HAE-nC1INH (6 carriers and 38 non-carriers of F12 mutation, n = 44) during remission or attack periods. Remission period refers to >48 hrs after symptoms disappearance; attack period refers to <24 hrs after symptom onset. ***, P<0.0001.
