Table 2. Standardized incidence ratios (SIRs) for human papillomavirus (HPV)-associated malignancies among female survivors of pediatric and young adult (PAYA) cancers, 1973 to 2010.

					95% CLb
Cancer type		Observed	Expected	SIR	LLc	ULd
HPV-associated cancers a	Overalle	105	72.64	1.4	1.2	1.8
	No radiationf	64	53.16	1.2	0.93	1.5
	Radiationg	41	19.48	2.1	1.6	2.9
Anogenital cancers	Overall	85	66.64	1.3	1.0	1.6
	No radiation	52	48.63	1.1	0.81	1.4
	Radiation	33	18.01	1.8	1.3	2.5
Analh	Overall	7	4.36	1.6	0.70	3.2
	No radiation	5	3.31	1.5	0.55	3.3
	Radiation	2	1.05	1.9	0.32	6.3
Cervical	Overall	55	55.05	1.0	0.77	1.3
	No radiation	35	39.90	0.88	0.63	1.2
	Radiation	20	15.15	1.3	0.85	2.0
Vaginal	Overall	9	1.48	6.1	3.0	11
	No radiation	5	1.12	4.5	1.6	9.9
	Radiation	4	0.36	11	3.5	27
Vulvar	Overall	14	5.75	2.4	1.4	4.1
	No radiation	7	4.30	1.6	0.71	3.2
	Radiation	7	1.45	4.8	2.1	9.5
Head and neck	Overall	20	6.00	3.3	2.2	5.2
	No radiation	12	4.53	2.6	1.4	4.5
	Radiation	8	1.47	5.4	2.5	10
Tongue	Overall	16	4.25	3.8	2.2	6.0
	No radiation	11	3.18	3.5	1.8	6.0
	Radiation	5	1.07	4.7	1.7	10
Tonsillar	Overall	4	1.49	2.7	0.85	6.5
	No radiation	1	1.14	0.88	0.04	4.3
	Radiation	3	0.35	8.6	2.2	23
Oropharyngeal	Overall	0	0.26	0	0	Undefined
	No radiation	0	0.21	0	0	Undefined
	Radiation	0	0.05	0	0	Undefined

^aIncludes anal, cervical, vaginal, vulvar, tongue, tonsillar, and oropharyngeal cancers;

^bCL =  Confidence Limit;

^cLL =  Lower Limit;

^dUL =  Upper Limit;

^e n = 34,299 female cancer survivors;

^f n = 24,310 female cancer survivors not treated with radiation;

^g n = 9,989 female cancer survivors treated with radiation;

^hIncludes anus, anal canal, and anorectum.