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. 2013 Aug 5;8(8):e71754. doi: 10.1371/journal.pone.0071754

Figure 3. Pomalidomide (POM) showed significant pre-clinical therapeutic activity with prolongation of survival in two in vivo CNS lymphoma models.

Figure 3

Raji model: A-1, A-2 and A-3. OCI-LY10 model: B-1,B-2, and B-3. A-1. and B-1. Bioluminescence imaging of CNS lymphoma on day 18 post tumor implantation. A-2. and B-2. Luminescence signal of lymphoma growth post-intracerebral injection of 25,000 Raji cells or 1x105 OCI-LY10 cells. The data were shown as mean ±SEM (average radiance % baseline) for n=8. In vivo tumor growth in Pom- 3mg/kg, Pom-10mg/kg and Pom-30mg/kg groups were significantly slower than that in the control group. *, P<0.05, as compared with control. A-3. and B-3. Kaplan-Meier analysis showed prolongation of survival with Pom_3mg/kg, Pom_10mg/kg and Pom-30mg/kg treated groups (p < 0.05, n=8).