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. 2013 Aug 6;4:223. doi: 10.3389/fimmu.2013.00223

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Copyright © 2013 Walker, Marrinan, Muenchhoff, Ferguson, Kloverpris, Cheroutre, Barnes, Goulder and Klenerman.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Distinct CD8β expression levels are demonstrated on CD161++, CD161+, and CD161−CD8α+ T cell subsets. (A) Co-staining of PBMCs with anti-CD8α and anti-CD8β antibodies identifies a range of CD8β expression by CD3+CD4−CD8α+ T cells in both a HC and patient with HBV. (B) Distinct CD8β^high, CD8β^low, and CD8β^neg populations are demonstrated based on the level of CD161 expression (marked on the vertical gates on FACS plots as++/±). Representative FACS plots of both HC (n = 16) and patients with chronic HBV (n = 31) shown. (C) The size of the CD161−CD8α+ CD8β^low T cell population as a percentage of the CD161−CD8α+ population is compared between HCs and patients with chronic HBV, HCV, and HIV-1 infections. (*p < 0.05, **p < 0.001, One-way ANOVAs).