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. 2013 Aug 6;4:223. doi: 10.3389/fimmu.2013.00223

Figure 6.

Figure 6

CD161−CD8α+CD8βlow T cells express markers of late differentiation. (A) Representative FACS data comparing CD28, CD27, and CD57 expression by peripheral blood CD161−CD8α+CD8βlow and CD161−CD8α+CD8βhigh T cell populations as demonstrated by a patient with chronic HBV infection. (B) Cumulative data comparing CD28, CD27, and CD57 expression by peripheral blood CD161−CD8α+CD8βlow and CD161−CD8α+CD8βhigh T cell populations in HCs and patients with chronic HBV, HCV, and HIV-1 infections. CD161−CD8α+CD8βhigh T cell and CD161−CD8α+CD8βlow T cells represented on graphs by filled and unfilled shapes respectively. (**p < 0.001, ***p < 0.0001, Wilcoxon signed rank test). (C) Representative FACS data comparing CD57 and CD28 expression between CD3+CD161− TL-tetramer+ and CD3−CD161− TL-tetramer – cells in a patient with chronic HBV. (D) Cumulative data comparing CD57 and CD28 expression between CD3+CD161− TL-tetramer+ and CD3+CD161− TL-tetramer – cells for patients with HBV, HCV, and HIV-1 infections (**p < 0.001, Wilcoxon signed rank test).