Figure 7.

CD161−CD8α+CD8βlow T cells express markers of activation and exhaustion. (A) Representative FACS data comparing HLA-DR expression between peripheral blood CD161−CD8α+CD8β^low and CD161−CD8α+CD8β^high T cell populations. (B) Cumulative data comparing HLA-DR expression between CD161−CD8α+CD8β^low and CD161−CD8α+CD8β^high T cell populations in HCs and patients with chronic HBV and HCV. CD161−CD8α+CD8β^high T cell and CD161−CD8α+CD8β^low T cells represented on graphs by filled and unfilled shapes respectively. (**p < 0.001, ***p < 0.0001, Wilcoxon signed rank test). (C) Comparison of PD-1 expression by CD8 T cells in patients with chronic HBV and HCV infections compared to HCs (**p < 0.001, One-way ANOVA). (D) Comparison of PD-1 expression by CD161−CD8α+CD8β^low and CD161−CD8α+CD8β^high T cell populations in chronic HBV and HCV (**p < 0.001, Wilcoxon signed rank test).