Figure 3.

Based on a meta-analysis Hedman et al. (2011) constructed the following TBV plots over the life span from approximately age 4 through 90 years of age. A hypothetical TBI patient injured in their 20's sustaining a volume loss of a 100 cc is depicted with the inference being that although only chronologically a young adult, because of the brain loss, the total reduction of TBV is similar to someone in their 7th decade of life (downward arrow, X-axis). In other words, purely from a TBV perspective, TBI accelerated brain volume loss. Reproduced with permission from Wiley.