Figure 6.

(TOP) Mid-sagittal section through the corpus callosum showing initial atrophy 1-year from TBI, but increasing atrophy within this WM structure expressed over the next 8 years, indicating late neurodegenerative effects on WM. Images reproduced with permission from Tomaiuolo et al. (2012) and Elsevier Science. (BOTTOM) Corpus callosum tractography extracted from DTI in a control, compared to a child with severe TBI. The mid-sagittal MRI shows gross thinning of the posterior corpus callosum (dark arrow) but DTI actually demonstrates that this reduced area actually has regions of no DTI-identifiable aggregate WM tracts. Adapted from Wilde et al. (2006b) used with permission from Mary Ann Liebert Publishing.