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. 2013 Feb 26;471(9):2776–2782. doi: 10.1007/s11999-013-2871-4

Table 1.

Incidence of severe heterotopic ossification, including data reported in randomized trials and historic data

Author Moderate or severe radiographic HO (Brooker III and IV)
No prophylaxis or placebo Indomethacin Radiation
Current study 21% (25/120)
Karunakar et al. [13] 19% (12/62) 15% (9/59)
Letournel and Judet* [14] 11% (31/281)
Matta and Siebenrock [15] 5% (1/21) 9% (3/32)
Burd et al. [6] 11% (8/72) 4% (3/78)

* Letournel used Kocher-Langenbeck, no prophylaxis; only includes patients treated through a posterior or extensile approach; HO = heterotopic ossification. Table provided by and modified with permission from SLACK Incorporated: Karunakar MA. Acetabular fractures: heterotopic ossification. In: Archdeacon MT, Anglen JO, Ostrum RF, Hersocovici D Jr. Prevention and Management of Common Fracture Complications. Thorofare, NJ, USA: Slack Inc; 2012:179–188.