Table 1.
Mean (± SD) values for pharmacokinetic parameters of BPA after iv, sublingual, and orogastric BPA dosing.
| Pharmacokinetic parametera | iv | Sublingual | Orogastric | ||
|---|---|---|---|---|---|
| 0.05mg/kg | 5mg/kg | 0.05mg/kg | 5mg/kg | 20mg/kg | |
| Cmax (ng/mL) | 64±36 | 7,296±1,615 | 249±331 | 6,443±3,910 | 47±20 |
| Tmax (min) | 2±0 | 3±1 | 10±4 | 13±9 | 20±8 |
| AUClast (× 103ng/min/mL) | 1±0 | 221±54 | 2±1 | 145±44* | 6±2 |
| MRT (min) | NC | 69±13 | NC | 73±33 | 112±37 |
| BPA bioavailability (%) | NA | NA | NC | 70±31 | 0.72±0.28 |
| Abbreviations: NA, not applicable; NC, not calculated. aThe first 8 min following the end of sublingual administration were not taken into account in deriving the BPA pharmacokinetic parameters. *p ≤0.05, compared with iv administration of the same BPA dose by Student’s t-test. | |||||