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. Author manuscript; available in PMC: 2014 Jun 1.
Published in final edited form as: Genes Chromosomes Cancer. 2013 Mar 5;52(6):10.1002/gcc.22050. doi: 10.1002/gcc.22050

Figure 3. Spindle cell rhabdomyosarcoma with TEAD1-NCOA2 fusion.

Figure 3

Tumor from a 4 week-old baby boy who was born with a chest wall mass (case RMS4). (A) It is composed of short fascicles of spindle cells that have somewhat myofibroblastic appearance, infiltrating adjacent skeletal muscle. (B) A more cellular high grade component was also noted arranged in intersecting fascicles and associated with a high mitotic activity. Tumor cells demonstrate patchy positivity for Desmin and focal nuclear reactivity for myogenin (C) (A-C, original magnification 200×). (D) Partial karyotype showing a t(8;11) translocation. (E) Direct sequencing of the RT-PCR product confirmed the fusion of the TEAD1 exon 8 with NCOA2 exon 13. (F) FISH assay demonstrated TEAD1 and NCOA2 fusion-signal (highlighted with blue arrows; probes centromeric to NCOA2 in red, probes telomeric to TEAD1 in green).