Table 2.
Summary of Previously Reported ERMS with a t(2;8) Translocation or Involving the 8q12-13 Locus by Conventional Karyotyping
| Diagnosis | Age/Sex | Location | Morphologya | Karyotype | Reference |
|---|---|---|---|---|---|
| Congenital ERMS |
27 wks fetus/M | Cervical (cheek) |
Round and spindle cells (undifferentiated) |
t(2;8)(q35;q21.2)? | (Yoshino et al., 2005) |
| Congenital ERMS |
2 wk/M | Perineal gluteal/ rectal |
Round and spindle cells, rare strap cells (undifferentiated) |
t(2;8)(q35;q13) PAX3-NCOA2 |
(Meloni-Ehrig et al.,2009; Sumegi et al.,2010) |
| Congenital ERMS |
27 wks fetus (at birth)/F |
Upper eyelid | Spindle cells, rare Rblasts (no illustrations) |
t(2;8)(q35;q13) | (Hayashi et al., 1988) |
| ERMS | 8 mo/M | Pelvis/bladder | Round and spindle cells (undifferentiated) |
t(2;12;8)(q11.2;q22;q13) PAX3 rearrangement by FISH |
(Hosoi et al., 2009) |
| ERMS (botryoides) |
2 yrs/F | Abdominal | Round and spindle cells, myxoid stroma |
t(8;11)(q12-13;q21) | Calabrese et al., 1992) |
M, male; F, female; ERMS, embryonal rhabdomyosarcoma; Rblasts, rhabdomyoblasts, mo, months; wks, weeks; yrs, years.
a
Listed in parenthesis is the authors of this article interpretation of the morphology illustrated in the referenced publications.