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. Author manuscript; available in PMC: 2013 Aug 6.
Published in final edited form as: Acta Physiol (Oxf). 2011 Jan 27;203(1):245–251. doi: 10.1111/j.1748-1716.2010.02230.x

Figure 2.

Figure 2

Effect of age and diabetes on myogenic reactivity of isolated MCAs over the pressure range. (a) Vessels from 10-week-old animals constricted in response to increasing intraluminal pressure displaying normal myogenic reactivity and under passive conditions, there was full relaxation with no difference between control and diabetic animals. (b) While 18-week control animals maintained this ability, diabetic animals showed impaired pressure-induced reactivity. (c) There was a disease and age interaction that MCA myogenic tone at 80 mmHg was increased in 10-week diabetic animals but significantly reduced at 18 weeks. Metformin treatment improved tone development. Mean ± SEM, n=7–14, * p<0.05 vs control, **p<0.001 vs 10-week diabetes, ***p<0.05 vs diabetes.