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. Author manuscript; available in PMC: 2013 Aug 6.
Published in final edited form as: J Urol. 2013 Feb 27;190(2):757–764. doi: 10.1016/j.juro.2013.02.090

Figure 1.

Figure 1

Confocal images show harvested rat bladders instilled with antisense OND with 5′ tag of TYE 563 without liposome (A), and with OND complexed with liposomes at 8 (B) and at 24 (C) hours. Bright red fluorescence demonstrates successful uptake and retention in target cells of OND delivered by liposomes (B and C). Fluorescence was more homogenous in urothelium at 24 hours vs discrete localization to lumen surface at 8 hours. Arrow indicates lumen side. Bright field image is also shown since there was no fluorescent signal for image to be taken for group instilled with antisense OND with 5′ tag of TYE 563 without liposome (A). Absence of red fluorescence reveals liposome need for successful bladder uptake of OND. Reduced from ×40.