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. Author manuscript; available in PMC: 2013 Aug 6.
Published in final edited form as: J Urol. 2013 Feb 27;190(2):757–764. doi: 10.1016/j.juro.2013.02.090

Figure 2.

Figure 2

CMG analysis of bladder overactivity in treated groups induced by intravesical application of 0.25% AA. Representative CMG was performed 24 hours after instillation of saline in sham treated group (Sham), liposomal complex of scrambled OND or antisense OND (A). Note CMG traces 30 to 10 minutes before and 60 to 90 minutes after AA application. AA-induced reduction in ICI was seen in sham and scrambled OND treated rats but not in group treated with liposomal NGF antisense complex which demonstrates antisense OND protective effect. CMG parameters in absence of AA did not significantly differ in 3 groups. Changes in ICI after intravesical AA application expressed as percent of control ICI before AA (B). AA induced ICI decrease was significantly smaller in liposome-NGF antisense treated group vs sham and liposome-scrambled OND treated groups. Asterisk indicates p <0.05.