Table II. Comparison of growth factor signaling determined by phosphoproteomics and mouse phospho-RTK array analyses. The results present as signaling altered (+), down-regulated (↓) or unchanged ( - ) in Ext1−/− MLECs compared to Ext1f/f MLECs. Note: * - the EphB signaling shown in general is altered in phosphoproteomic analysis, and in the p-RTK array assay the EphB1/2/4/6 were observed to be down-regulated; # - the EphA signaling shown in general is altered in phosphoproteomic analysis, and in the p-RTK array assay the EphA1/3/6/8 were down-regulated and the EphA2/7 were unchanged.

Signaling pathway	Phosphoproteomics	Mouse Phospho-RTK Array
IGF-1/Insulin receptor	+	↓
VEGF	+	↓
Neuregulin/NGF	+	↓
HGF	+	↓
PDGF	+	↓
EGF	+	↓
Angiopoietin/Tie	+	↓
FGF	+	↓
GDNF/c-Ret	+	↓
ErB2/3/4	+	↓
EphB*	+	↓
EphA#	+	↓/-
Mer	-	-