Table V. Tumour enriched candidate genes.
| Gene | Product | Gene Ontology cell component | Analysis | Human peptides | % Unigene brain ESTs | Rembrandt database | Total abstracts | Glioma keyword abstracts |
|---|---|---|---|---|---|---|---|---|
| TNC | Tenascin C | Extracellular | Human peptides | 3 | 12 | Up in glioma | 156 | 15 |
| FN1 | Fibronectin 1 | Extracellular | Human peptides | 3 | 5 | Up in glioma | 433 | 7 |
| TGFBI | Transforming growth factor, beta-induced, 68 kDa | Membrane | Human peptides | 3 | 19 | Up in glioma | 172 | 5 |
| HRNR | Hornerin | Extracellular | Human peptides | 2 | 0 | Not found | 14 | 0 |
| COL4A1 | Collagen, type IV, alpha 1 | Extracellular | Human peptides | 1 | 4 | Up in glioma | 132 | 2 |
| SIRPA | Signal-regulatory protein alpha | Membrane | Cast cluster | 0 | 39 | Not differential | 81 | 4 |
| SRPX | Sushi-repeat containing protein, X-linked 2 | Extracellular | Cast cluster | 0 | 17 | Not differential | 19 | 1 |
| PLXND1 | Plexin D1 | Membrane | Cast cluster | 0 | 15 | Not differential | 20 | 0 |
| FSTL1 | Follistatin-like 1 | Extracellular | Cast cluster | 0 | 9 | Up in glioma | 25 | 0 |
| LOXL2 | Lysyl oxidase-like 2 | Extracellular | Cast cluster | 0 | 7 | Up in glioma | 37 | 0 |
Note: This table lists the 10 candidate tumor enriched genes chosen for immunohistochemistry validation. Attributes reported are the number of human-specific peptides matching a gene, the percentage of total Unigene cluster expressed sequence tags (ESTs) expressed in brain for a gene, a Rembrandt database glioma enriched profile, total PubMed article abstracts, and the number of abstracts that contain one or more of the following keywords: glioma, glioblastoma, astrocytoma, and neuroblastoma.