Table 1.
Basic characteristic between responders and nonresponders
| Characteristics | All patients (n = 35) | Responders (n = 20) | Nonresponders (n = 15) | p value |
|---|---|---|---|---|
| Age (years) | 38.7 ± 11.5 | 36.5 ± 10.5 | 41.8 ± 12.5 | 0.214 |
| Sex (male %) | 33 (94) | 19 (57.7) | 14 (42.4) | 1.000 |
| Weight, median (IQR) | 77.0 (66.6–81.0) | 77.2 (66.05–80.75) | 77.0 (72.50–86.00) | 0.043 |
| Serum ALT (IU l−1) | 80 (59–143) | 94 (67–195) | 71 (43–84) | 0.034 |
| Serum HBV DNA (log copies ml−1) | 6.6 (5.7–7.8) | 5.8 (5.5–6.8) | 7.8 (6.6–7.8) | 0.004 |
| Serum HbsAg (log IU ml−1) | 4.0 (3.7–4.4) | 4.0 (3.7–4.6) | 3.9 (3.7–4.3) | 0.882 |
| Hemoglobin (gm l−1) | 154 (144–163) | 154 (142–167) | 153 (144–157) | 0.221 |
| Leucocyte count (109 l−1) | 5.6 (4.8–6.9) | 6.0 (5.0–7.3) | 5.2 (4.2–5.8) | 0.064 |
| Platelets (109 l−1) | 225 (177–266) | 220 (177–264) | 243 (177–301) | 0.379 |
| Bilirubin (μmol l−1) | 11 (9–14) | 10 (9–14) | 11 (7–18) | 0.908 |
| Alkaline phosphatase (U l−1) | 87 (76–121) | 90 (70–134) | 86 (80–120) | 0.888 |
| GGT (IU l−1) | 51 (32–78) | 46 (32–78) | 53 (33–79) | 0.939 |
| α-Fetoprotein (μg l−1) | 4.3 (3.1–6.2) | 4.0 (2.7–5.4) | 5.6 (4.1–8.8) | 0.093 |
| Albumin (g l−1) | 45 (40–46) | 44 (41–46) | 45 (40–48) | 0.749 |
| Cholesterol (mmol l−1) | 4.3 (3.8–5.0) | 4.3 (3.8–4.9) | 4.3 (3.8–5.3) | 0.674 |
| Triglycerides (mmol l−1) | 1.29(0.79–1.85) | 0.80(0.645–1.283) | 1.85(1.30–2.10) | 0.002 |
| Liver biopsy: grade A1 and A2 (METAVIR classification) (%) | 33 (94) | 17 (51.5) | 16 (48.5) | 0.489 |
| Liver biopsy: stage F1 and F2 (METAVIR classification) (%) | 29 (83) | 15 (51.7) | 14 (48.2) | 0.666 |
Median (IQR)