Figure 2.

Absolute changes from baseline in percent of predicted FEV₁ and Cystic Fibrosis Questionnaire-revised (CFQ-R) respiratory domain scores, and absolute sweat chloride concentrations by study group. (A) Absolute mean change from baseline (± SEM) in percent of predicted FEV₁. (B) Absolute mean change from baseline (± SEM) in the CFQ-R respiratory domain score (child questionnaire version). (C) Sweat chloride concentrations (± SEM) from baseline to Week 48. The orange dashed line indicates 60 mmol/L, the recognized diagnostic cut-off. In A, B, and C, estimates are model-based.