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Caspase-3, JNK, and p38 signaling are hyperactivated in LKB1-null MEFs in response to AICAR. Immunoblot analysis on LKB1 WT or -null MEFs without treatment (NT) or 5 h after treatment with 2 mM AICAR. Cleaved (activated) caspase-3, poly(ADP-ribose) polymerase (PARP), phospho-JNK (P-JNK), phospho-p38 (P-p38), phospho-AKT (P-AKT; Ser-473), and total Akt were detected by immunoblotting (Cell Signaling Technology).
