Figure 1.

Abridged schematics for regulation of transient receptor potential canonical 5 (TRPC5) (left) and TRPC6 (right) channels by lipids in simplified mammalian cells. See the main text for details. Examples of regulation by other factors are included, but are not exhaustive. Abbreviations not provided in the main text are: Gd³⁺, gadolinium; Pb²⁺, lead; rTRX, reduced thioredoxin; OxPLR, putative oxidized phospholipid receptor (identity unknown); H₂O₂, hydrogen peroxide; chol., cholesterol; podo., podocin; AA, arachidonic acid. G_i/o and G_q/11 are different types of GTP-binding proteins. The integral phospholipase C (PLC) and phospholipase A₂ (PLA₂) enzymes are not shown. TRPC6 may also be stimulated through receptor tyrosine kinase (Hamdollah Zadeh et al. 2008, Ge et al. 2009). Tian et al. (2010) should be consulted for the proposed distinction of TRPC5 coupling to cell movement and TRPC6 to contraction. Vesicular trafficking of TRPC5 has been described in response to growth factors (Bezzerides et al. 2004).