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. 2013 May 17;52(24):6283–6287. doi: 10.1002/anie.201301167

Scheme 2.

Scheme 2

Kinetic isotope effect study. Reaction conditions: i) B2pin2 (1.3 equiv), Pd(OAc)2 (2 mol %), BQ (1.1 equiv), LiOAc⋅2H2O (20 mol %), DCE, 50 °C, 1 h. ii) B2pin2 (1.3 equiv), Pd(OAc)2 (2 mol %), BQ (1.1 equiv), BF3⋅Et2O (20 mol %), THF, 50 °C, 1 h for b) and 20 h for c). E=CO2Me.