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. 2004 Feb 6;101(10):3338–3345. doi: 10.1073/pnas.0307875101

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Fig. 4. — Vascular defects in Fbw7^-/- yolk sacs and embryos. (A–C) Fbw7^+/+ yolk sac at ED9.5. (A) Gross appearance of yolk sac. (B, C, E, and F) Images stained with hematoxylin (blue) and eosin (red). (B) Histologic analysis of yolk sac demonstrates abundant large and small vessels with rich blood islands. (C) High magnification of boxed area from B shows mature vessel with intact blood island. (D–F) Fbw7^-/- yolk sac at ED9.5. (D) Gross appearance of yolk sac. (E) Histologic appearance of Fbw7^-/- yolk sac confirms the absence of a mature vasculature. (F) Higher magnification of the area indicated in the box in E. (G–J) Platelet endothelial cell adhesion marker 1 immunocytohistochemistry (stained in brown and counterstained with hematoxylin in blue) reveals neural tube vasculature at ED9.5. (G and H) Fbw7^+/+ embryo at ×10 and ×20 magnification, respectively. (I and J) Fbw7^-/- embryo at ×20 and ×40 magnification, respectively.