Table 4.

Polymorphisms associations with focal malaria-associated seizures. (A) Site-specific and (B) pooled analysis across sites

(A)
	Blantyre, Malawi			Kilifi, Kenya			Kumasi, Ghana			Muheza, Tanzania
Polymorphism	Odds ratio	p-value	Model	Odds ratio	p-value	Model	Odds ratio	p-value	Model	Odds ratio	p-value	Model
IL20RA rs1555498	0.50 (0.15–1.70)	0.27119	add	0.93 (0.48–1.82)	0.83213	gen	0.26 (0.03–2.17)	0.211485	add	3.86 (1.67–8.93)	0.00168	rec
CD36 rs3211938	0.65 (0.17–2.44)	0.524159	dom	1.47 (0.81–2.70)	0.20875	het	10.16 (1.79–57.83)	0.00894	het	1.53 (0.56–4.22)	0.402252	het

(B)
			Pooled analysis across the four sites
Gene			Odds ratio (95% CI)		p-value							Model
–			–		–							–

Genotypic tests with a p-value ≤ 0.009 are reported, with comparisons from other sites (on adjustment for multiple testing, a p-value of ≤0.009 was considered to represent true genotypic tests). The logistic model was adjusted for age, sex, ethnicity, and history of adverse perinatal events. Model denotes the inheritance pattern of interest: add = additive, dom = dominant, het = heterozygous, and rec = recessive. The cells with missing data (–) represents genotypic tests, which did not reach significant levels in the pooled analysis. Polymorphisms are represented as HUGO gene symbol and rs number.