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. 2013 Jun 4;21(8):1486–1496. doi: 10.1038/mt.2013.115

Figure 4.

Figure 4

Efficacy study of AAV6-PRDX3 and AAV6-NRF2 in SOD1G93A mice. (a) Changes in neurological score (average score per group) over time in experimental mice (N = 15 mice per group, two-way analysis of variance, Bonferroni's post-hoc test, P < 0.05, mean ± SEM). (b) Comparison of the average age of onset between experimental groups as calculated by neurological scoring (N = 15 mice per group, two-way analysis of variance, Bonferroni's post-hoc test, P < 0.05, mean ± SEM). (c) Rotarod performance (i.e., ability of mice to run in seconds) over time between experimental groups with the dashed line depicting a 20% reduction in rotarod performance (N = 15 mice per group; two-way analysis of variance, Bonferroni's post-hoc test, P < 0.05, mean ± SEM). (d) Kaplan–Meier plot to compare lifespan between all experimental groups (N = 15 per group; P < 0.05). (e,f) Representative lumbar spinal cord sections from untreated control SOD1G93A mice, fixed and stained with Nissl substance. Scale bars are shown at the bottom right corner (e, 200 μm; f, 100 μm). (g) Quantification of motor neurons (average number per section per group) by counting across all groups (N = 5; one-way analysis of variance, Bonferroni's post-hoc test, P < 0.05, mean ± SEM). AAV6, adenoassociated virus serotype 6; GFP, green fluorescent protein; NRF2, nuclear factor erythroid 2–related factor 2; PRDX3, peroxiredoxin 3.