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. 2013 Jun 4;21(8):1579–1591. doi: 10.1038/mt.2013.78

Figure 4.

Figure 4

Cotransplantation of dopamine (DA) neurons with Semaphorin 3–expressing cells elicits functional recovery. (a) Cografts of DA neurons in the SN with transfected HEK293 cells caused significant behavioral recovery after apomorphine challenge. (b) In keeping with this, the adjusting step test showed significant improvement when either Sema3A or Sema3C were combined with intranigral DA neuron grafts. (c) Forelimb placing and (d) cylinder tests revealed that Sema3C, together with DA neurons, were effective in reverting motor deficits in hemiparkinsonian animals. *P < 0.05 and **P < 0.01 versus DA neurons only and also versus DA neurons plus mock-transfected HEK293 cells.