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. 2004 Feb 25;101(10):3381–3386. doi: 10.1073/pnas.0400282101

Fig. 1.

Fig. 1.

Age-related decline in total hepatic GSH is due to loss in GCL activity and expression. Hepatic GSH levels in young (3 mo; n = 4) and old (24 mo; n = 4) F344 rats are shown in A. Results show a 35% decline in total GSH [GSH + 2 glutathione disulfide (GSSG)] in old relative to young rats. (B) Measurement of GCL activity reveals a significant 54.8% decline with age. Western analysis of GCL subunits shows that decreased GCL activity was, in part, due to the lower levels of GCLC and GCLM in old relative to young rats (C). Results are expressed as the mean ± SEM.