Table 3.

Copper-Catalyzed Amination of 8-Amino-quinoline Amides^[a]

entry	amine	product	yield, %
1	HNMeBn		82
2	HNMePr		74
3	4-EtO2C- piperidine		69
4	4-NC- piperidine		71
5	Ethylene ketal of 4-keto- piperidine		82
6	4-BocNH- piperidine		83
7	Cyclohexyl- amine		40
8	Cyclooctyl- amine		52
9	Neopentyl- amine		32
10[b]	n-C12H25NH2		20

^[a]Scale: 0.5 mmol, 2 mL NMP, 2 equiv NMO, 2 equiv amine, 12-25 mol% Cu(OAc)₂, 12-25 mol% Ag₂CO₃, 110 °C, 12 h. Yields are isolated yields.

^[b]Pyridine solvent. Please see Supporting Information for details.