Table 4.
Comparison of performance between control and LOAD cohorts on neurocognitive measures and domains
| Cognitive domains | Control (n=187) | LOAD (n=168) | Z score | P value |
|---|---|---|---|---|
| Logical Memory Ia | 9.46 (4.25) | 6.45 (2.12) | −3.92 | <.0001 |
| Logical Memory IIa | 8.29 (3.12) | 5.34 (2.33) | −3.09 | .001 |
| Episodic Memory Composite | 3.57 (2.64) | 1.32 (1.36) | −3.15 | <.0001 |
| Digit Span Forward | 8. 98 (2.16) | 4.47 (1.24) | −3.15 | <.0001 |
| Trail Making Test part A | 26.72 (23.69) | 64.57 (26.74) | −3.64 | <.0001 |
| Attention Domain Composite | 11.11 (9.58) | 3.24 (7.23) | −3.03 | <.0001 |
| Trail Making Test part B | 79.87 (32.25) | 192.34 (53.12) | −2.93 | <.0001 |
| Digit Span Backward | 7.23 (2.12) | 4.82 (2.05) | −2.67 | <.0001 |
| Executive Function Composite | 3.56 (1.63) | 1.31 (1.28) | −2.66 | <.0001 |
| Fluency (animals) | 16.21 (5.23) | 16.34 (3.97) | −0.98 | .21 |
| Fluency (vegetables) | 15.57 (4.98) | 14.98 (3.28) | −0.29 | .12 |
| Semantic Memory Composite | 2.81 (1.78) | 1.39 (1.02) | −0.51 | .10 |
| Clocking drawing test | 7.58 (3.12) | 7.02 (2.89) | −1.09 | .29 |
Data are presented as mean and (standard deviation).
LOAD=Late Onset Alzheimer’s Disease.