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. 2013 Feb 21;4(2):e502. doi: 10.1038/cddis.2013.1

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Copyright © 2013 Macmillan Publishers Limited

This work is licensed under the Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/

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CUL1 siRNA inhibits invasion and migration of HTR8/SVneo cells. (a) Confirmation of RNA interference of CUL1 was shown by western blotting. (b, c) Upper panels: representative images of filters containing invaded cells in matrigel invasion assay (b) and transwell cell migration assay (c) are shown; Middle panels: the number of invaded or migrated cells in a 100 × random field; Lower panels: Statistical bar graphs showing the summary of three independent experiments (t-test; *P<0.05; **P<0.01)