Figure 4.

Domain architecture of bacterial type I and metacaspase-like proteases identified in a wide range of bacterial groups. Metacaspase-like proteases are widespread in most bacterial groups, (including cyanobacteria and archaea) whereas type I metacaspases are found in fewer groups (including β-Proteobacteria, δ-Proteobacteria, Actinobacteria and Nitrospirae). Bacterial type I metacaspases exhibit a slightly longer interdomain linker than type I metacaspases in eukaryotes. Species abbreviations are: Cn, Candidatus Nitrospira defluvii; Gs, Geobacter sulfurreducens; Lc, Leptothrix cholodnii; Mp, Methylibium petroleiphilum; Rf, Rhodoferax ferrireducens; Sa, Streptomyces avermitilis; Ss, Streptomyces scabiei. The total lengths of metacaspase-like proteases are not represented because of high variance