Table 3. Meta-analysis results for the TP53 rs17878362 polymorphism by cancer type.
| Genotypes | Cases, n (%) | Controls, n (%) | Heterogeneity P-value | OR | (95% CI) | P-trenda |
|---|---|---|---|---|---|---|
| Breast (Study numbers: 3, 11, 12, 13, 15, 25; MAF=0.17) | ||||||
| Total | 2 028 (100.0) | 1 748 (100.0) | ||||
| A1A1 | 1 307 (64.5) | 1 212 (69.3) | 1.00 | — | <0.01 | |
| A1A2 | 642 (31.7) | 483 (27.6) | 0.57b | 1.18 | (1.02–1.37) | |
| A2A2 | 79 (3.9) | 53 (3.0) | 0.08b | 1.41 | (0.97–2.06) | |
| Colon (study numbers: 8, 17, 20, 21, 23; MAF=0.15) | ||||||
| Total | 1 637 (100.0) | 1 686 (100.0) | ||||
| A1A1 | 1 143 (69.8) | 1 214 (72.0) | 1.00 | — | 0.08 | |
| A1A2 | 453 (27.7) | 444 (26.3) | 0.04* | 1.15 | (0.87–1.50) | |
| A2A2 | 41 (2.5) | 28 (1.7) | 0.33b | 1.67 | (1.02–2.74) | |
| Lung (study numbers: 18, 19, 25; MAF=0.13) | ||||||
| Total | 4 054 (100.0) | 4 045 (100) | ||||
| A1A1 | 2 977 (73.4) | 3 076 (76.0) | 1.00 | — | <0.01 | |
| A1A2 | 979 (24.2) | 898 (22.2) | 0.02* | 1.22 | (0.96–1.54) | |
| A2A2 | 98 (2.4) | 71 (1.8) | 0.03* | 1.46 | (0.71–3.00) | |
Abbreviations: CI, confidence interval; MAF, minor allele frequency; OR, odds ratio
*Heterogeneity P-value ≤0.05: performed random model for meta-analysis
a
Fisher's exact test
b
Heterogeneity P-value >0.05: performed fixed model for meta-analysis