Table 4.

—Typical Hemodynamics and Pitfalls in Distinguishing PAH From PH Due to HFpEF

PAH (mPAP > 25 mm Hg)	PH Due to HFpEF (mPAP > 25 mm Hg)	Pitfalls and Additional RHC Maneuvers
Normal PCWP/LVEDP	Elevated PCWP/LVEDP	PAH may have mild elevation in left-sided filling pressures.63
		HFpEF may have normal left-sided filling pressures after aggressive diuresis. Consider fluid or exercise challenge.88
		PCWP may not be an accurate estimate of LAP or LVEDP. Consider direct measurement of LVEDP.89
PVR > 2.5-3 WU	PVR ≤ 2.5-3 WU (passive)	It is a misconception that patients with PH due to LHD will not have an elevated PVR.
	PVR > 2.5-3 WU (mixed)

LAP = left atrial pressure; LVEDP = left ventricular end-diastolic pressure; mPAP = mean pulmonary arterial pressure; PCWP = pulmonary capillary wedge pressure; PVR = pulmonary vascular resistance; RHC = right-sided heart catheterization; WU = Wood units. See Table 1 and 3 legends for expansion of other abbreviations.