Figure 8.

Gga proteins and AP-1 act with clathrin in Golgi-to-endosome transport. In this model, Kex2p, CPS, and Vps10p are packaged into clathrin-coated vesicles for transport to endosomes. ALP is sorted into AP-3–dependent, clathrin-independent vesicles for transport directly to the vacuole. The two arrows leading to the endosomal system signify the possibilities that AP-1 and Gga proteins act in separate clathrin-dependent pathways or act in the same clathrin-dependent pathway but exhibit different cargo selectivities. See DISCUSSION for details.