Table 3.
Hazard ratios (HR) for selected reproductive factors reported at baseline and lung cancer risk in subcohort of female textile workers, 1989–1998
| Reproductive Factor | Cases (N=60 2) |
Non- cases (N=3035 ) |
MODEL 1 HR (95% CI)a |
MODEL 2 HR (95% CI)b |
||
|---|---|---|---|---|---|---|
| Live Birth History | ||||||
| 0 (never pregnant or past pregnancy, no live birth) | 33 | 122 | 1.00 | referent | 1.00 | referent |
| 1 | 76 | 704 | 0.79 | (0.48–1.32) | 0.81 | (0.48–1.36) |
| 2 | 93 | 537 | 0.69 | (0.43–1.11) | 0.70 | (0.44–1.13) |
| 3 | 153 | 608 | 0.82 | (0.53–1.28) | 0.84 | (0.54–1.32) |
| 4 | 110 | 496 | 0.66 | (0.42–1.04) | 0.67 | (0.43–1.07) |
| ≥5 | 137 | 568 | 0.66 | (0.42–1.03) | 0.68 | (0.43–1.06) |
| p trend* | 0.24 | p trend* | 0.26 | |||
| Hysterectomyc | ||||||
| Never | 563 | 2909 | 1.00 | referent | 1.00 | referent |
| Ever | 38 | 122 | 1.26 | (0.85–1.85) | 1.26 | (0.85–1.87) |
| Oophorectomyc | ||||||
| Never | 568 | 2914 | 1.00 | referent | 1.00 | referent |
| Ever | 30 | 101 | 1.42 | (0.92–2.19) | 1.39 | (0.90–2.16) |
| Unilateral | 6 | 37 | 1.14 | (0.45–2.88) | 1.06 | (0.42–2.70) |
| Bilateral | 24 | 64 | 1.51 | (0.93–2.45) | 1.51 | (0.92–2.46) |
All analyses exclude subjects who ever worked as machinists (n = 114), worked with wool (n = 17), or in sanitation jobs (n = 44)
a
Adjusted for age at baseline (continuous) and smoking (ever/never)
b
Adjusted for age at baseline (continuous), smoking (ever/never), and quartile of endotoxin exposure (no lag)
*
Trend includes parous women only
c
Postmenopausal women only