Table 2. Genotype and allele frequencies of TP53 and MDM2 genes among the patients and controls and their associations with male infertility.
| Genotype | Cases | Controls | Crude OR | Adjusted OR | P-valueb | |||
|---|---|---|---|---|---|---|---|---|
| n | (%) | n | (%) | (95% CI) | (95% CI)a | Genotype | Allele | |
| TP53 72Arg>Pro (rs1042522) | 0.361 | 0.146 | ||||||
| GG | 154 | (26.6) | 170 | (29.3) | 1.00 | 1.00 | ||
| GC | 270 | (46.6) | 273 | (47.1) | 1.09 (0.83–1.44) | 1.05 (0.79–1.38) | ||
| CC | 156 | (26.9) | 137 | (23.6) | 1.26 (0.92–1.73) | 1.20 (0.88–1.65) | ||
| GC+CC | 426 | (73.4) | 410 | (70.7) | 1.15 (0.89–1.48) | 1.10 (0.85–1.42) | ||
| TP53 Ex2+19C>T (rs2287498) | 0.0002 | <0.001 | ||||||
| CC | 239 | (41.2) | 296 | (51.0) | 1.00 | 1.00 | ||
| CT | 254 | (43.8) | 234 | (40.3) | 1.34 (1.05–1.72) | 1.32 (1.03–1.69) | ||
| TT | 87 | (15.0) | 50 | (8.6) | 2.15 (1.46–3.17) | 2.11 (1.44–3.11) | ||
| CT+TT | 341 | (58.8) | 284 | (49.0) | 1.49 (1.18–1.88) | 1.46 (1.16–1.84) | ||
| MDM2 5′ UTR T>G (rs937283) | 0.011 | 0.004 | ||||||
| TT | 120 | (20.7) | 149 | (25.7) | 1.00 | 1.00 | ||
| TG | 295 | (50.9) | 306 | (52.8) | 1.21 (0.90–1.61) | 1.13 (0.85–1.51) | ||
| GG | 165 | (28.4) | 125 | (21.6) | 1.65 (1.18–2.31) | 1.55 (1.11–2.16) | ||
| TG+GG | 460 | (79.3) | 431 | (74.3) | 1.31 (1.00–1.72) | 1.23 (0.93–1.61) | ||
Abbreviations: 5′ UTR, 5′ untranslated region; CI, confidence interval; OR, odds ratio.
a
Adjusted for age, smoking and drinking status.
b
Two-sided chi-squared test for the distributions of genotype and allele frequencies.
P for Hardy-Weinberg (HW) equilibrium: rs1042522, P=0.181; rs2287498, P=0.698; rs937283, P=0.170.