Table 3. Combined effect of TP53 Ex2+19C>T and MDM2 5′ UTR T>G on male infertility risk.
| TP53 Ex2+19C>T (rs2287498) | MDM2 5′ UTR T>G (rs937283) | Cases, n (%) | Controls, n (%) | OR (95% CI)a |
|---|---|---|---|---|
| CC | TT | 47 (8.1) | 86 (14.8) | 1.00 |
| CC | TG/GG | 192 (33.1) | 210 (36.2) | 1.57 (1.05–2.35) |
| CT/TT | TT | 73 (12.6) | 63 (10.9) | 1.99 (1.22–3.23) |
| CT/TT | TG/GG | 268 (46.2) | 221 (38.1) | 1.95 (1.32–2.90) |
| Pinteractionb | 0.055 |
Abbreviations: 5′ UTR, 5′ untranslated region; CI, confidence interval; OR, odds ratio.
a
Odds ratio was adjusted for age, smoking and drinking status.
b
Pinteraction for additive interaction.