Table 1. Kinetics and thermodynamics of mAbs D44.1 and F10.6.6 reactions with lysozyme at 25°C.

mAb	Ka*, M−1·s−1	Kd*, s−1	Ka, M−1	ΔG, KJ/mol	ΔH†, KJ/mol	−TΔS, KJ/mol
D44.1	4.21 × 104	2.92 × 10−3	1.44 × 107	−40.5†	−43.3	2.8†
F10.6.6	7.19 × 106	7.00 × 10−4	1.02 × 1010	−56.6‡	−76.4	19.8‡

^*Determined by IAsys biosensor (this work) using Fab fragments.

^†Taken from Schwarz et al. (29).

^‡Calculated from the equations ΔG = −RT InK_a and ΔG = ΔH − TΔS