Table 3. Linear regression analysis of joint relationship of genotypes and maternal urinary phthalate with genital distance measures (adjusted for center, age and infant weight percentile), Study for Future Families II, 1999–2005.
| Genotype | Measure | Phthalate | Phthalate* genotype interaction term coefficient (95% CI) | P value | |
|---|---|---|---|---|---|
| rs2077647 | AA or AG | AGD | Sum DEHP Metabolites (MEHP/MEOHP/MEHHP) | −1.3 (−6.0, 3.4) | 0.58 |
| MEP | −2.0 (−4.8, 0.8) | 0.16 | |||
| MBP | 0.1 (−4.4, 4.5) | 0.97 | |||
| rs10475 | TT or TC | ASD | Sum DEHP metabolites (MEHP/MEOHP/MEHHP) | −0.8 (−4.2, 2.7) | 0.67 |
| MEP | 0.01 (−2.1, 2.1) | 0.99 | |||
| MBP | −0.7 (−4.2, 2.9) | 0.71 |
Abbreviations: AGD, anogenital distance; ASD, anoscrotal distance; MBP, mono-butyl phthalate; MEHHP, mono-(2-ethyl-5-hydroxyhexyl) phthalate; MEHP, mono(2-ethylhexyl) phthalate; MEOHP, mono-(2-ethyl-5-oxohexyl) phthalate; MEP, mono-ethyl phthalate.
*Refers to a statistical interaction term to examine how phthalate modify the relationship between genotype and outcome.