Antibody reactivity to peptides of other autoantigens. Average reactivity of rabbit sera before immunization (B and D Insets) and 4 months after immunization with A3 (A and C) and A6 (B and D) with select overlapping octapeptides of nRNP 70K, A, and C, and Sm B/B′ and Sm D1. These epitopes are areas commonly bound by human lupus patient sera. (A and B) Octapeptides 1-49 are from nRNP 70K, 50-87 are from nRNP A, and 88-115 are from nRNP C. (C and D) Octapeptides 1-34 are from Sm B/B′, whereas 35-50 are from Sm D1.