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. 2013 Jul 16;6:25–32. doi: 10.2147/TACG.S33966

Figure 1.

Figure 1

Genes of the autophagy pathway implicated in Crohn’s disease susceptibility.

Notes: There are several phases in the autophagic pathway. Initiation is the formation of the preautophagolysosome, elongation, maturation, followed by fusion of the lysosome and degradation of the cargo.

Abbreviations: LRRK2, leucine-rich repeat kinase 2; IRGM, immunity-related GTPase family M protein; NOD2, nucleotide-binding oligomerization domain-containing protein 2; CARD15, caspase recruitment domain-containing protein 15; ATG16L1, autophagy-related protein 16–1; GTP, guanosine triphosphate; ULK1, serine/threonine kinase.