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. 2011 Jan 12;31(2):439–452. doi: 10.1523/JNEUROSCI.3420-10.2011

Figure 6.

Figure 6.

LASSO-PCR based accuracy for predicting placebo analgesia from anticipatory activity within three a priori sets of regions. A, Regions identified in each meta-analysis. Blue, Consistent activations related to executive working memory in a meta-analysis of 60 studies (Wager and Smith, 2003). Red, Consistent activations related to emotional tasks in a meta-analysis of 163 studies (Kober et al., 2008). Yellow, Results from a mega-analysis of 114 participants who underwent a thermal pain challenge in our laboratory (the pain-processing network localizer; see supplemental Fig. 4, available at www.jneurosci.org as supplemental material). B, Prediction accuracy from LASSO-PCR for each set of regions, compared with the “null” model based only on training-set placebo analgesia scores. Only the emotion-related regions showed an above-chance (*p < 0.05) reduction in prediction error. C, Prediction (x-axis)–outcome (y-axis) scatter plots for each set of regions.