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. 2011 Dec 26;14(1):14–23. doi: 10.1038/aja.2011.168

Figure 1.

Figure 1

First drawing of mammalian spermatozoa by A. van Leeuwenhoek (around 1677) that inspired this description by C. Huygens (1678). ‘…They are formed of a transparent substance, their movements are very brisk and their shape is similar to that of frogs before their limbs are formed.' Note the clear identification of heads, mid-pieces and tails and the remarkable morphologic heterogeneity of sperm heads.