Figure 1.
First drawing of mammalian spermatozoa by A. van Leeuwenhoek (around 1677) that inspired this description by C. Huygens (1678). ‘…They are formed of a transparent substance, their movements are very brisk and their shape is similar to that of frogs before their limbs are formed.' Note the clear identification of heads, mid-pieces and tails and the remarkable morphologic heterogeneity of sperm heads.