Table 1. Intracytoplasmic sperm injection (ICSI) outcome in patients with defective chromatin condensation (nuclear vacuoles).
| Author | Treatment | Number of oocytesper cycle | Fertilizationrate (%) | Goodembryos (%) | Implantationrate (%) | Pregnancyrate (%) | Miscarriage rate (%) |
|---|---|---|---|---|---|---|---|
| Bartoov et al.,28 2003 | ICSI IMSI | 50 50 | 65.5 64.5 | 31 45.2* | 9.5 27.9* | 30 60* | 33 9.0* |
| Hazout et al.,97 2006 | ICSI IMSI | 125 125 | 65.2 68.1 | 32.6 42.6 | 0.8 20.3* | 2.4 37.6* | 100 15* |
| Berkovitz et al.,98 2006 | ICSI IMSI | 80 80 | 69.1 67.4 | 25.7 38.7* | 9.4 31.3* | 25 60* | 40 14* |
| Antinori et al.,99 2008 | ICSI IMSI | 219 227 | 94.5 94.8 | — — | 11.3 17.3* | 26.5 39.2* | 24.1 16.9 |
| Wilding et al.,100 2011 | ICSI IMSI | 8 8 | 79.4 70.1 | 60.3 83.6* | 0 20.8* | 0 37.5 | — — |
| Balaban et al.,101 2011 | ICSI IMSI | 84 84 | 80.9 81.6 | — — | 19.5 28.9 | 44.4 54.0 | — — |
| Oliveira et al.,102 2011 | ICSI IMSI | 100 100 | 62 65.4 | — — | 13.6 9.8 | 26 19 | 15.4 31.6 |
Abbreviation: IMSI, intracytoplasmic injection of morphologically selected spermatozoa.
Women age: 30–37 years.
Number of transferred embryos: 2–4.
*P<0.05, compared with ICSI.