Table 2. Intracytoplasmic sperm injection (ICSI) outcome in globozoospermia and acrosomal hypoplasia.
| Author | Number of patients (cycles) | Fertilization rate | Results |
|---|---|---|---|
| Dirican et al.,103 2008 | 2 globozoospermic brothers (1 ICSI cycle each) | First cycle, 33%, with CI Second cycle, 9.1%, without CI | XX live birth, 38 weeks XX live birth, 38 weeks |
| Tejera et al.,104 2008 | 1 globozoospermic man (1 ICSI cycle) | With CI, 55.6% Without CI, 35.7% | XX live birth, 40 weeks Without transfer |
| Kyono et al.,105 2009 | 1 globozoospermic man (1 ICSI cycle) | With CI, 88.2% | XX live birth 40 weeks |
| Banker et al.,106 2009 | 2 globozoospermic patients (2 ICSI cycles each) | First patient, 2 cycles. Without CI (30.7% and 28.6%) Second patient, 2 cycles. Without CI (20% and 12.5%) | Without pregnancy Miscarriage (5 weeks) Without pregnancy XY live birth, 37 weeks |
| Egashira et al.,107 2009 | 1 globozoospermic man (2 ICSI cycles) | Without electrical activation, 0% With electrical activation, 100% | Without transfer XX live birth, 37 weeks |
| Taylor et al.,108 2010 | 1 globozoospermic man (ICSI cycle) | With CI, 100% | Ongoing pregnancy7 weeks |
| Sermondade et al.,109 2011 | 1 man w/acrosomal hypoplasia (1 ICSI cycle; spermatozoa selected by IMSI) | Without CI, 60% With CI, 66% | XY live birth, 38 weeks Without transfer |
Abbreviations: CI, Ca++ ionophore; IMSI, intracytoplasmic injection of morphologically selected spermatozoa.