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. 2004 Feb 26;101(10):3650–3655. doi: 10.1073/pnas.0306587101

Fig. 3.

Fig. 3.

Morphine-induced behavioral effects in tPA-/- and plg-/- mice. (A) Development of tolerance to the antinociceptive effect of morphine (10 mg/kg s.c.) in tPA-/- mice. (B and C) Morphine (3 and 10 mg/kg s.c.)-induced place preference in tPA-/- mice (B) and plg-/- mice (C). (D) Locomotor activity and locomotor sensitization induced by morphine (10 mg/kg s.c.) treatment. (E) Effect of tPA and plasmin microinjection into the NAcc on locomotor activity induced by morphine (10 mg/kg s.c.) in the tPA-/- mice. (F) Apomorphine (0.3 and 1.0 mg/kg s.c.)-induced hyperlocomotion. Values indicate means ± SE (n = 4-5 for A, n = 8 -21 for B, n = 6 -12 for C, n = 10 for D, n = 8 for E, and n = 8 for F). *, P < 0.05 and **, P < 0.01 compared to corresponding saline-treated mice. #, P < 0.05 compared to corresponding morphine-treated wild-type mice. $, P < 0.05 and $$, P < 0.01 compared to vehicle plus morphine-treated tPA-/- mice. †, P < 0.05 compared to corresponding vehicle-treated mice.